Publications | Dierickx Lab

Circadian transcriptional repressors REV-ERBα/β and E4BP4 regulate cardiac function

Yilian Wang, Pieterjan Dierickx

Journal of Molecular and Cellular Cardiology · 01 Nov 2025

Chronotherapy as a novel strategy to limit anthracycline-induced cardiotoxicity

Ilse R Kelters, Markella I Printezi, Annabelle Ballesta, Pieterjan Dierickx, Yvonne Koop, Pasquale F Innominato, Francis A Lévi, J Corne Van Dam, Pieter A Doevendans, Alwin D R Huitema, Arco J Teske, Anne M May, Joost P G Sluijter, Linda W Van Laake

Cardiovascular Research · 06 Oct 2025

Chronotherapy Cardiotoxicity Doxorubicin

BMAL1 is a Critical Regulator of Sex-Specific Gene Expression in the Heart

Pieterjan Dierickx

Function · 22 Jan 2025

Circadian Rhythms Cardiac Function BMAL1

Circadian rhythms in cardiovascular dysfunction: approaches for future therapeutics

Margaux Lecacheur, Daniëlle J. M. Ammerlaan, Pieterjan Dierickx

npj Cardiovascular Health · 23 Sep 2024

Human circadian rhythms Cardiac Function Therapeutics

Cardiomyocyte-specific disruption of the circadian BMAL1–REV-ERBα/β regulatory network impacts distinct miRNA species in the murine heart

Mary N. Latimer, Lamario J. Williams, Gobinath Shanmugan, Bryce J. Carpenter, Mitchell A. Lazar, Pieterjan Dierickx, Martin E. Young

Communications Biology · 10 Nov 2023

Circadian Rhythms miRNAs REV-ERBs

NAD+ controls circadian rhythmicity during cardiac aging

Bryce J. Carpenter, Margaux Lecacheur, Yannick N. Mangold, Kai Cui, Stefan Günther, Pieterjan Dierickx

Genomics · 08 Nov 2023

NAD+Circadian Rhythms Aging Transcriptional Regulation

Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology

Sobuj Mia, Ravi Sonkar, Lamario Williams, Mary N. Latimer, David R. Rawnsley, Samir Rana, Jin He, Pieterjan Dierickx, Teayoun Kim, Min Xie, Kirk M. Habegger, Masato Kubo, Lufang Zhou, Morten B. Thomsen, Sumanth D. Prabhu, Stuart J. Frank, Paul S. Brookes, Mitchell A. Lazar, Abhinav Diwan, Martin E. Young

JACC: Basic to Translational Science · 14 Jun 2023

Cardiac Metabolism Circadian Clock Transcriptional Regulation

RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure

Tsunehisa Yamamoto, Santosh K. Maurya, Elizabeth Pruzinsky, Kirill Batmanov, Yang Xiao, Sarah M. Sulon, Tomoya Sakamoto, Yang Wang, Ling Lai, Kendra S. McDaid, Swapnil V. Shewale, Teresa C. Leone, Timothy R. Koves, Deborah M. Muoio, Pieterjan Dierickx, Mitchell A. Lazar, E. Douglas Lewandowski, Daniel P. Kelly

Journal of Clinical Investigation · 16 Mar 2023

Cardiac metabolism Heart Failure Nuclear Receptors

Circadian cardiac NAD⁺ metabolism, from transcriptional regulation to healthy aging

Bryce J. Carpenter, Pieterjan Dierickx

American Journal of Physiology-Cell Physiology · 05 Sep 2022

NAD+Circadian Rhythms Aging Cardiomyocyte Clock

Nicotinamide Riboside Improves Cardiac Function and Prolongs Survival After Disruption of the Cardiomyocyte Clock

Pieterjan Dierickx, Bryce J. Carpenter, Isaac Celwyn, Daniel P. Kelly, Joseph A. Baur, Mitchell A. Lazar

Frontiers in Molecular Medicine · 09 May 2022

REV-ERB Cardiomyocyte Clock NAD+circadian clock

Circadian REV-ERBs repress E4bp4 to activate NAMPT-dependent NAD+ biosynthesis and sustain cardiac function

Pieterjan Dierickx, Kun Zhu, Bryce J. Carpenter, Chunjie Jiang, Marit W. Vermunt, Yang Xiao, Timothy S. Luongo, Tsunehisa Yamamoto, Íngrid Martí-Pàmies, Sobuj Mia, Mary Latimer, Abhinav Diwan, Juanjuan Zhao, Amy K. Hauck, Brianna Krusen, Hoang C. B. Nguyen, Gerd A. Blobel, Daniel P. Kelly, Liming Pei, Joseph A. Baur, Martin E. Young, Mitchell A. Lazar

Nature Cardiovascular Research · 23 Dec 2021

REV-ERB E4bp4 NAD+circadian clock

Cardiac circadian rhythms in time and space: The future is in 4D

Nino Chirico, Linda W. Van Laake, Joost P.G. Sluijter, Alain van Mil, Pieterjan Dierickx

Current Opinion in Pharmacology · 15 Dec 2020

Circadian rhythms Regeneration Stem cells Tissue engineering Clock manipulation Extracellular matrix

The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation

Poonam Dhillon, Jihwan Park, Carmen Hurtado del Pozo, Lingzhi Li, Tomohito Doke, Shizheng Huang, Juanjuan Zhao, Hyun Mi Kang, Rojesh Shrestra, Michael S. Balzer, Shatakshee Chatterjee, Patricia Prado, Seung Yub Han, Hongbo Liu, Xin Sheng, Pieterjan Dierickx, Kirill Batmanov, Juan P. Romero, Felipe Prósper, Mingyao Li, Liming Pei, Junhyong Kim, Nuria Montserrat, Katalin Susztak

Cell Metabolism · 09 Dec 2020

PT cell differentiation ESRRA protects Kidney Disease scRNA-seq analysis

The hepatocyte clock and feeding control chronophysiology of multiple liver cell types

Dongyin Guan, Ying Xiong, Trang Minh Trinh, Yang Xiao, Wenxiang Hu, Chunjie Jiang, Pieterjan Dierickx, Cholsoon Jang, Joshua D. Rabinowitz, Mitchell A. Lazar

Science · 30 Jul 2020

Circadian Rhythms Liver Metabolism snRNA-seq

SR9009 has REV-ERB–independent effects on cell proliferation and metabolism

Pieterjan Dierickx, Matthew J. Emmett, Chunjie Jiang, Kahealani Uehara, Manlu Liu, Marine Adlanmerini, Mitchell A. Lazar

Proceedings of the National Academy of Sciences · 24 May 2019

REV-ERB Hepatocytes ES cells Metabolism Circadian Rhythms

Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response

Wenxiang Hu, Chunjie Jiang, Dongyin Guan, Pieterjan Dierickx, Rong Zhang, Arden Moscati, Girish N. Nadkarni, David J. Steger, Ruth J.F. Loos, Cheng Hu, Weiping Jia, Raymond E. Soccio, Mitchell A. Lazar

Cell Stem Cell · 10 Jan 2019

PPARγ Patient-specific Response Adipocytes TZDs

Circadian clocks: from stem cells to tissue homeostasis and regeneration

Pieterjan Dierickx, Linda W Van Laake, Niels Geijsen

EMBO reports · 19 Dec 2017

Circadian rhythms Stem Cells Aging Metabolism Regeneration

Neonatal rat cardiomyocytes as an in vitro model for circadian rhythms in the heart

Bastiaan C. du Pré, Pieterjan Dierickx, Sandra Crnko, Pieter A. Doevendans, Marc A. Vos, Niels Geijsen, Didi Neutel, Toon A.B. van Veen, Linda W. van Laake

Journal of Molecular and Cellular Cardiology · 18 Aug 2017

Circadian rhythms Heart In vitro Neonatal rat cardiomyocytes

SCA1 + Cells from the Heart Possess a Molecular Circadian Clock and Display Circadian Oscillations in Cellular Functions

Bastiaan C. Du Pré, Evelyne J. Demkes, Dries A.M. Feyen, Pieterjan Dierickx, Sandra Crnko, Bart J.M. Kok, Joost P.G. Sluijter, Pieter A. Doevendans, Marc A. Vos, Toon A.B. Van Veen, Linda W. Van Laake

Stem Cell Reports · 10 Aug 2017

SCA1 circadian rhythm clock heart progenitor cell stem cell

Bright Bioluminescent BRET Sensor Proteins for Measuring Intracellular Caspase Activity

Anniek den Hamer, Pieterjan Dierickx, Remco Arts, Joost S. P. M de Vries, Luc Brunsveld, Maarten Merkx

ACS Sensors · 31 May 2017

caspase sensor BRET NanoLuc mNeonGreen plate reader assay single-cell imaging

Circadian networks in human embryonic stem cell-derived cardiomyocytes

Pieterjan Dierickx, Marit W Vermunt, Mauro J Muraro, Menno P Creyghton, Pieter A Doevendans, Alexander van Oudenaarden, Niels Geijsen, Linda W Van Laake

EMBO reports · 23 May 2017

circadian clock heart

Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair

Malte Tiburcy, James E. Hudson, Paul Balfanz, Susanne Schlick, Tim Meyer, Mei-Ling Chang Liao, Elif Levent, Farah Raad, Sebastian Zeidler, Edgar Wingender, Johannes Riegler, Mouer Wang, Joseph D. Gold, Izhak Kehat, Erich Wettwer, Ursula Ravens, Pieterjan Dierickx, Linda W. van Laake, Marie Jose Goumans, Sara Khadjeh, Karl Toischer, Gerd Hasenfuss, Larry A. Couture, Andreas Unger, Wolfgang A. Linke, Toshiyuki Araki, Benjamin Neel, Gordon Keller, Lior Gepstein, Joseph C. Wu, Wolfram-Hubertus Zimmermann

Circulation · 06 Feb 2017

Heart Failure Engineered Human Myocardium

Dual Readout BRET/FRET Sensors for Measuring Intracellular Zinc

Stijn J. A. Aper, Pieterjan Dierickx, Maarten Merkx

ACS Chemical Biology · 01 Sep 2016

BRET/FRET

Muscle-on-chip: An in vitro model for donor–host cardiomyocyte coupling

Pieterjan Dierickx, Linda W. Van Laake

Journal of Cell Biology · 08 Feb 2016

Adhesion Biophysics Cell signaling Cytoskeleton Membrane and lipid biology Physiology Stem cells Systems and Computational Biology

Circadian Rhythms in Stem Cell Biology and Function

Pieterjan Dierickx, Bastiaan Du Pré, Dries A. M. Feyen, Niels Geijsen, Toon van Veen, Pieter A. Doevendans, Linda W. Van Laake

Stem Cell Biology and Regenerative Medicine · 18 Dec 2015

Circadian rhythms Stem Cells Aging Metabolism Regeneration

Efficient ROSA26-Based Conditional and/or Inducible Transgenesis Using RMCE-Compatible F1 Hybrid Mouse Embryonic Stem Cells

Lieven Haenebalcke, Steven Goossens, Michael Naessens, Natascha Kruse, Morvarid Farhang Ghahremani, Sonia Bartunkova, Katharina Haigh, Tim Pieters, Pieterjan Dierickx, Benjamin Drogat, Omar Nyabi, Dagmar Wirth, Jody J. Haigh

Stem Cell Reviews and Reports · 23 Jul 2013

ES cells Differentiation Reprogramming Transgenics

The ROSA26-iPSC Mouse: A Conditional, Inducible, and Exchangeable Resource for Studying Cellular (De)Differentiation

Lieven Haenebalcke, Steven Goossens, Pieterjan Dierickx, Sonia Bartunkova, Jinke D’Hont, Katharina Haigh, Tino Hochepied, Dagmar Wirth, Andras Nagy, Jody J. Haigh

Cell Reports · 07 Feb 2013

ES cells Differentiation Reprogramming Transgenics Regeneration

Embryonic Template-Based Generation and Purification of Pluripotent Stem Cell-Derived Cardiomyocytes for Heart Repair

Pieterjan Dierickx, Pieter A. Doevendans, Niels Geijsen, Linda W. van Laake

Journal of Cardiovascular Translational Research · 18 Jul 2012

Cardiomyocyte differentiation In Vitro Regeneration