Bryce’s paper on circadian reprogramming during cardiac aging is out!

We are very happy to share the publication of our latest research article: https://lnkd.in/dukqDRQV in Communications Biology.

We found that with aging, NAD+ levels drop in the heart. Concomitantly diurnal rhythms are reprogrammed during aging, which we could partially prevent by long-term treatment with NR, and NAD precursor. This long-term treatment also prevented naturally occurring cardiac enlargement with aging. Interestingly we found that with aging it’s not so much core clock gene expression that is affected, but PER2 protein oscillations. In addition, we found that part of the NR-response genes were SIRT1-dependent. These findings shed light on how the circadian clock in the heart is rewired with aging and how cardiac metabolism is interlinked with the circadian clock during aging. Hopefully this will help to pave the way for chronotherapy-based strategies to prevent and treat aging-related cardiac disorders.

Major congratulations to first author Bryce Carpenter and all lab members involved for their hard work. I feel blessed with such a great team and am very proud of their tenacity and accomplishments. Onwards and upwards!

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